Science for athletes
The science
behind the
Enhanced Games.
Pioneering clinical research, comprehensive medical profiling, and cutting-edge enhancement science.
Science for athletes
The science
behind the
Enhanced Games.
Pioneering clinical research, comprehensive medical profiling, and cutting-edge enhancement science.
THE ENHANCED GAMES SCIENCE PROGRAM
THE ENHANCED GAMES SCIENCE PROGRAM
Pioneering the science
of human enhancement.
Enhanced Science is the integrated research, safety, and performance optimisation framework that supports elite athletes in the Enhanced Games. It brings together pioneering clinical research, comprehensive medical profiling, and cutting-edge enhancement science to set a new standard for safety, performance, and human potential.
Enhanced Science is the integrated research, safety, and performance optimisation framework that supports elite athletes in the Enhanced Games. It brings together pioneering clinical research, comprehensive medical profiling, and cutting-edge enhancement science to set a new standard for safety, performance, and human potential.
Scientific
Integrity & Impact
Scientific
Integrity & Impact
IRB-approved research generating the world’s first structured dataset on supervised enhancement — with implications for recovery, longevity, metabolic health, and human optimisation for all.
IRB-approved research generating the world’s first structured dataset on supervised enhancement — with implications for recovery, longevity, metabolic health, and human optimisation for all.
Medical Safety
& Supervision
Medical Safety
& Supervision
Comprehensive profiling, proactive risk mitigation, and continuous clinical oversight by independent commissions and world-class medical centres.
Comprehensive profiling, proactive risk mitigation, and continuous clinical oversight by independent commissions and world-class medical centres.
Enhancement
Protocols
Enhancement
Protocols
Personalised performance optimisation across training, recovery, nutrition, and medically supervised PES — tailored to each individual’s physiology and goals.
Personalised performance optimisation across training, recovery, nutrition, and medically supervised PES — tailored to each individual’s physiology and goals.
THE 2026 ENHANCED GAMES
A new standard for athlete safety and performance.
What is the Enhanced Games?
What is the Enhanced Games?
The Enhanced Games is a global annual sports competition that celebrates human potential. Athletes are permitted to use select, medically supervised performance-enhancing substances (PES) within a transparent and regulated framework.
The inaugural Enhanced Games took place on 24th May 2026 in Las Vegas during Memorial Day Weekend, covering sprint-distance track, sprint-distance swimming, Olympic weightlifting, and Deadlift events.
The Enhanced Games was established to replace secrecy and unsupervised enhancement use with transparency, science, and rigorous medical oversight.
This isn’t just about improving performance. It’s about raising the standard of medical care across elite sport.
The Enhanced Games is a global annual sports competition that celebrates human potential. Athletes are permitted to use select, medically supervised performance-enhancing substances (PES) within a transparent and regulated framework.
The inaugural Enhanced Games took place on 24th May 2026 in Las Vegas during Memorial Day Weekend, covering sprint-distance track, sprint-distance swimming, Olympic weightlifting, and Deadlift events.
The Enhanced Games was established to replace secrecy and unsupervised enhancement use with transparency, science, and rigorous medical oversight.
This isn’t just about improving performance. It’s about raising the standard of medical care across elite sport.
Athlete safety at the Enhanced Games
Athlete safety at the Enhanced Games
All athletes competing at the Enhanced Games receive the most comprehensive medical profiling and supervision of their careers — not focused on punitive drug testing, but on health protection, performance optimisation, and long-term wellbeing.
All athletes competing at the Enhanced Games receive the most comprehensive medical profiling and supervision of their careers — not focused on punitive drug testing, but on health protection, performance optimisation, and long-term wellbeing.
Comprehensive medical supervision serves two purposes:
Comprehensive medical supervision serves two purposes:
1
To address existing gaps in athlete care
To address existing gaps in athlete care
The gap in athlete care
The gap in athlete care
Elite sport places extraordinary demands on the body, yet athlete health assessments have not kept up with advancements in systems medicine. Unexplained underperformance, burnout, hormonal disruption, and mental health challenges remain widespread, and personalised biomarker tracking and physiological profiling are rarely used, despite their potential to improve recovery, adaptation, resilience, and overall athlete health. Enhanced was built to close that gap.
Elite sport places extraordinary demands on the body, yet athlete health assessments have not kept up with advancements in systems medicine. Unexplained underperformance, burnout, hormonal disruption, and mental health challenges remain widespread, and personalised biomarker tracking and physiological profiling are rarely used, despite their potential to improve recovery, adaptation, resilience, and overall athlete health. Enhanced was built to close that gap.
2
To allow for safe performance enhancing substance use
To allow for safe performance enhancing substance use
Safe enhancement use
Safe enhancement use
When people hear ‘performance-enhancing substances’, they often think of health risks and danger, but it is not the use of these substances that is inherently dangerous, it’s the misuse. Many PES used by athletes are already prescribed safely to millions of people worldwide every year for legitimate medical purposes, for example testosterone injections routinely used for individuals who underproduce this hormone or struggle to maintain muscle mass.
Most of the data behind safety concerns of PES in athletes come from outdated and poorly designed scientific studies, with no biomarker tracking, clinical supervision, accurate dosing, or use of pure substances (Maron, 2009; Torrisi, 2020; Malhotra et al., 2018). With proper medical supervision — including tools to assess heart and organ health, and biomarker tracking — the risk associated with taking substances can be significantly reduced.
When people hear ‘performance-enhancing substances’, they often think of health risks and danger, but it is not the use of these substances that is inherently dangerous, it’s the misuse. Many PES used by athletes are already prescribed safely to millions of people worldwide every year for legitimate medical purposes, for example testosterone injections routinely used for individuals who underproduce this hormone or struggle to maintain muscle mass.
Most of the data behind safety concerns of PES in athletes come from outdated and poorly designed scientific studies, with no biomarker tracking, clinical supervision, accurate dosing, or use of pure substances (Maron, 2009; Torrisi, 2020; Malhotra et al., 2018). With proper medical supervision — including tools to assess heart and organ health, and biomarker tracking — the risk associated with taking substances can be significantly reduced.
What medical supervision do athletes receive?
What medical supervision do athletes receive?
All athletes who competed in the Enhanced Games underwent a rigorous medical screening process to ensure safety to compete, enhanced and natural alike. These assessments were performed at baseline upon joining Enhanced, during training, before competition, and after competition. Examples of the assessments included:
All athletes who competed in the Enhanced Games underwent a rigorous medical screening process to ensure safety to compete, enhanced and natural alike. These assessments were performed at baseline upon joining Enhanced, during training, before competition, and after competition. Examples of the assessments included:
CARDIAC
CARDIAC
Blood, Urine & Saliva
Blood, Urine & Saliva
Neurologic
Neurologic
Respiratory
Respiratory
Body Composition
Body Composition
Musculoskeletal
Musculoskeletal
Abdominal Organ Health
Abdominal Organ Health
MENTAL HEALTH
MENTAL HEALTH
Athlete Enhancement
How athletes were enhanced
How athletes were enhanced
Enhancement is not a single substance. It is the full ecosystem of tools and practices that improve human performance – from how an athlete trains to how they recover, fuel, and push their physiology further.
There are many ways to enhance athletic performance. These include coaching, training design and environment, recovery tools, nutrition, wearable technologies, and performance-enhancing substances (PES), among other factors that collectively contribute to overall enhancement.
At Enhanced, we take a holistic approach to performance improvement, considering all domains of enhancement, while focusing our primary innovation on PES. A PES regimen refers to a medically designed and supervised plan for the safe use of performance-enhancing substances over a defined period, typically 6–20 weeks.
Every regimen was individually tailored and continuously monitored. All substances used were FDA-approved and prescribed by a clinician, or administered as part of our IRB-approved research study. Enhanced does not provide or advocate for substances with poor safety profiles, no recognised medical use, or high abuse potential.
Enhancement is not a single substance. It is the full ecosystem of tools and practices that improve human performance – from how an athlete trains to how they recover, fuel, and push their physiology further.
There are many ways to enhance athletic performance. These include coaching, training design and environment, recovery tools, nutrition, wearable technologies, and performance-enhancing substances (PES), among other factors that collectively contribute to overall enhancement.
At Enhanced, we take a holistic approach to performance improvement, considering all domains of enhancement, while focusing our primary innovation on PES. A PES regimen refers to a medically designed and supervised plan for the safe use of performance-enhancing substances over a defined period, typically 6–20 weeks.
Every regimen was individually tailored and continuously monitored. All substances used were FDA-approved and prescribed by a clinician, or administered as part of our IRB-approved research study. Enhanced does not provide or advocate for substances with poor safety profiles, no recognised medical use, or high abuse potential.
An enhancement protocol refers to a coordinated plan involving substances or practices that:
An enhancement protocol refers to a coordinated plan involving substances or practices that:
An enhancement protocol refers to a coordinated plan involving substances or practices that:
Improve athletic attributes such as speed, strength, endurance, and skill
Improve athletic attributes such as speed, strength, endurance, and skill
Support recovery from illness, injury, or physical exertion
Support recovery from illness, injury, or physical exertion
Regulate hormone balance or mitigate side effects from other substances
Regulate hormone balance or mitigate side effects from other substances
Enhance overall health, mental wellbeing, and quality of life
Enhance overall health, mental wellbeing, and quality of life
IRB-approved research
The first IRB-approved study of its kind.
The Enhanced Games Research Study
The Enhanced Games Research Study
Enhanced has developed a groundbreaking research study in which all athletes competing in the 2026 Enhanced Games had the opportunity to participate. The purpose of this study is twofold: to administer performance-enhancing substances (PES) under strict medical supervision, and to advance scientific understanding in the field of human performance enhancement.
The primary goals of the study are to evaluate the tolerability and physiological effects of select PES in elite athletes. To support this, we have designed the most comprehensive athlete monitoring and safety protocol in the history of sport.
Enhanced has developed a groundbreaking research study in which all athletes competing in the 2026 Enhanced Games had the opportunity to participate. The purpose of this study is twofold: to administer performance-enhancing substances (PES) under strict medical supervision, and to advance scientific understanding in the field of human performance enhancement.
The primary goals of the study are to evaluate the tolerability and physiological effects of select PES in elite athletes. To support this, we have designed the most comprehensive athlete monitoring and safety protocol in the history of sport.
Biomarkers per athlete
935+
Blood data points collected
25,400+
Medical & scientific experts
28+
Long-term follow-up
5 Years
Safety oversight layers
7
WHAT IS AN IRB?
WHAT IS AN IRB?
An IRB, or Institutional Review Board, is an independent ethics committee responsible for reviewing and approving research involving human participants. Its primary role is to ensure that studies are conducted ethically, safely, and in compliance with regulatory standards, protecting the rights and well-being of all participants.
The Enhanced research study has been approved by an IRB based in the United Arab Emirates (UAE). This IRB operates in close partnership with the Department of Health (DoH) in Abu Dhabi, which oversees clinical trial approvals, licenses IRBs, and enforces ethical and scientific standards. Approval from this board ensures that our study meets the highest levels of participant protection, scientific integrity, and global regulatory compliance.
An IRB, or Institutional Review Board, is an independent ethics committee responsible for reviewing and approving research involving human participants. Its primary role is to ensure that studies are conducted ethically, safely, and in compliance with regulatory standards, protecting the rights and well-being of all participants.
The Enhanced research study has been approved by an IRB based in the United Arab Emirates (UAE). This IRB operates in close partnership with the Department of Health (DoH) in Abu Dhabi, which oversees clinical trial approvals, licenses IRBs, and enforces ethical and scientific standards. Approval from this board ensures that our study meets the highest levels of participant protection, scientific integrity, and global regulatory compliance.
What participation looked like
What participation looked like
Once an athlete was found eligible to join the study - based on specific inclusion and exclusion criteria, initial medical screening, and full informed consent - they completed a comprehensive baseline medical assessment. This included evaluations of their overall health, physiological function, and sport-specific performance. These assessments established each athlete’s individual baseline before any substances were introduced.
The medical team used this data to tailor a PES regimen based on the athlete’s unique physiology, health profiling results, and performance goals. The nine-week PES administration phase then began, during which participants underwent regular medical monitoring.
After the Enhanced Games, athletes repeated their baseline medical assessments to evaluate the effects of PES use on their health and performance. They then entered a five-year follow-up phase, which includes periodic medical evaluations and disclosure of any further PES use. This ensures continued monitoring of each athlete’s health and helps researchers understand long-term effects of PES use over time.
Once an athlete was found eligible to join the study - based on specific inclusion and exclusion criteria, initial medical screening, and full informed consent - they completed a comprehensive baseline medical assessment. This included evaluations of their overall health, physiological function, and sport-specific performance. These assessments established each athlete’s individual baseline before any substances were introduced.
The medical team used this data to tailor a PES regimen based on the athlete’s unique physiology, health profiling results, and performance goals. The nine-week PES administration phase then began, during which participants underwent regular medical monitoring.
After the Enhanced Games, athletes repeated their baseline medical assessments to evaluate the effects of PES use on their health and performance. They then entered a five-year follow-up phase, which includes periodic medical evaluations and disclosure of any further PES use. This ensures continued monitoring of each athlete’s health and helps researchers understand long-term effects of PES use over time.
Why we did
the study
Why we did
the study
This study generates a high-resolution, medically supervised dataset that addresses a gap in performance science. We have built the infrastructure to keep athletes safe while taking PES, and are tracking and publishing the data to back it up.
This study generates a high-resolution, medically supervised dataset that addresses a gap in performance science. We have built the infrastructure to keep athletes safe while taking PES, and are tracking and publishing the data to back it up.
High prevalence of unsupervised PES use
High prevalence of unsupervised PES use
PES have long been used without supervision by athletes seeking to extend careers or overcome under-addressed medical challenges.
PES have long been used without supervision by athletes seeking to extend careers or overcome under-addressed medical challenges.
Preventable
health burdens
Preventable
health burdens
Athletes face injury, underperformance, hormonal disruption, and burnout. Many turn to PES because conventional support systems fail them.
Athletes face injury, underperformance, hormonal disruption, and burnout. Many turn to PES because conventional support systems fail them.
Risk
mischaracterisation
Risk
mischaracterisation
PES risks stem from uncontrolled studies — often in bodybuilder populations — lacking biomarker monitoring, supervision, or dosage tracking.
PES risks stem from uncontrolled studies — often in bodybuilder populations — lacking biomarker monitoring, supervision, or dosage tracking.
Opportunity for innovation
Opportunity for innovation
As sanctioned PES use enters elite sport in the form of the Enhanced Games, the need for rigorous scientific inquiry intensifies.
As sanctioned PES use enters elite sport in the form of the Enhanced Games, the need for rigorous scientific inquiry intensifies.
The science is at the core of Enhanced — we are doing it properly with medical supervision, independent oversight, and a commitment to athlete safety.
SCIENTIFIC IMPACT
From elite athletes to everyday health.
From elite athletes to everyday health.
Elite athletes operate at the edge of human physiology — a uniquely informative environment where subtle physiological signals can be detected with a precision rarely possible in the general population. The insights that emerge flow directly into the science behind better health for everyone.
This study generates the world’s first structured, real-world dataset examining performance enhancement in elite, high-performance environments under continuous medical supervision, advancing understanding of dose-response relationships, safety thresholds, biomarker dynamics, and performance limits.
Beyond elite sport, this research addresses key public-health challenges, from injury prevention and metabolic health to stress resilience and healthy ageing. The science that begins with our athletes is designed to improve outcomes for everyone.
We are bringing longevity and performance enhancement into a credible, data-driven space.
We are bringing longevity and performance enhancement into a credible, data-driven space.
Elite athletes operate at the edge of human physiology — a uniquely informative environment where subtle physiological signals can be detected with a precision rarely possible in the general population. The insights that emerge flow directly into the science behind better health for everyone.
This study generates the world’s first structured, real-world dataset examining performance enhancement in elite, high-performance environments under continuous medical supervision, advancing understanding of dose-response relationships, safety thresholds, biomarker dynamics, and performance limits.
Beyond elite sport, this research addresses key public-health challenges, from injury prevention and metabolic health to stress resilience and healthy ageing. The science that begins with our athletes is designed to improve outcomes for everyone.
We are bringing longevity and performance enhancement into a credible, data-driven space.
We are bringing longevity and performance enhancement into a credible, data-driven space.
Dose-Response & Safety
Dose-Response & Safety
Structured data on safety thresholds, biomarker interactions, and performance limits.
Structured data on safety thresholds, biomarker interactions, and performance limits.
Recovery & Resilience
Recovery & Resilience
How the body repairs under extreme stress — and how those mechanisms translate to everyday health.
How the body repairs under extreme stress — and how those mechanisms translate to everyday health.
Metabolic & Hormonal Health
Metabolic & Hormonal Health
Energy efficiency, endocrine balance, and cellular repair with broad clinical applications
Energy efficiency, endocrine balance, and cellular repair with broad clinical applications
Advanced Diagnostics
Advanced Diagnostics
Novel biomarkers and monitoring technologies that redefine how health is measured.
Novel biomarkers and monitoring technologies that redefine how health is measured.
EXPERT OVERSIGHT
The experts
behind Enhanced.
Independent commissions of physicians, scientists, and researchers govern every aspect of athlete safety and scientific integrity.
Independent commissions of physicians, scientists, and researchers govern every aspect of athlete safety and scientific integrity.
23
Combined PhDs & MDs
Combined PhDs & MDs
12
Medical specialisms represented
Medical specialisms represented
350+
Years of combined research
Years of combined research
MEDICAL COMMISSION
MEDICAL COMMISSION
The Medical Commission plays a crucial role in safeguarding athlete well-being by establishing medical safety protocols, overseeing athlete medical profiling, and advising on eligibility and safety for competition in the Enhanced Games. Its independent oversight ensures that athlete health and safety remain the top priority.
The Medical Commission plays a crucial role in safeguarding athlete well-being by establishing medical safety protocols, overseeing athlete medical profiling, and advising on eligibility and safety for competition in the Enhanced Games. Its independent oversight ensures that athlete health and safety remain the top priority.
Commission Chair | Cardiology
Prof Guido Pieles, MD, D.Phil.
Commission Chair | Cardiology
Prof Guido Pieles, MD, D.Phil.
Sports and Preventive Medicine
Dr Michael Sagner, MD
Sports and Preventive Medicine
Dr Michael Sagner, MD
Neuroscience
Prof Brian Kopell, MD
Neuroscience
Prof Brian Kopell, MD
Immunology
Dr Leo Nissola, MD
Immunology
Dr Leo Nissola, MD
Sports Medicine
Dr Rodrigo Martínez Stenger, MD
Sports Medicine
Dr Rodrigo Martínez Stenger, MD
Pharmacology
Dr Ali Ghanem, PhD
Pharmacology
Dr Ali Ghanem, PhD
Sports Haematology
Dr Michael Ashenden, PhD
Sports Haematology
Dr Michael Ashenden, PhD
Female Health
Dr Klaudia Raczko, MD
Female Health
Dr Klaudia Raczko, MD
Internal Medicine
Dr. Abud Bakri, MD
Internal Medicine
Dr. Abud Bakri, MD
Longevity and Regenerative Medicine
Dr. Jonathann Kuo, MD
Longevity and Regenerative Medicine
Dr. Jonathann Kuo, MD
Regenerative Medicine
Dr Dominik Duscher, MD, PhD
Regenerative Medicine
Dr Dominik Duscher, MD, PhD
General
Dr Michael Martin, MD
General
Dr Michael Martin, MD
General
Dr Nick Prylinski, MD
General
Dr Nick Prylinski, MD
SCIENTIFIC COMMISSION
SCIENTIFIC COMMISSION
The Scientific Commission helps to shape Enhanced's research strategy and ensure scientific rigor. It supports the design and efficient execution of scientific studies while leveraging the members' collective expertise to further sports science research.
The Scientific Commission helps to shape Enhanced's research strategy and ensure scientific rigor. It supports the design and efficient execution of scientific studies while leveraging the members' collective expertise to further sports science research.
Prof Guido Pieles, MD, D.Phil.
Prof Guido Pieles, MD, D.Phil.
Prof George Church, Ph.D.
Prof George Church, Ph.D.
Prof Justin Stebbing, MD, Ph.D.
Prof Justin Stebbing, MD, Ph.D.
Dr Julia Cooney, MD, M.Phil.
Dr Julia Cooney, MD, M.Phil.
Prof Jose Antonio, Ph.D.
Prof Jose Antonio, Ph.D.
Prof Michael Rossbach, Ph.D.
Prof Michael Rossbach, Ph.D.
Imran Khan, M.Sc., M.Phil.
Imran Khan, M.Sc., M.Phil.
Prof John Nauright, Ph.D.
Prof John Nauright, Ph.D.
Dr Katherine Zagone, ND
Dr Katherine Zagone, ND
Alexander Bisignano
Alexander Bisignano
The same science that
enhances our athletes
can enhance you.
Scientifically validated performance and longevity protocols — rooted in the same research, backed by the same experts, held to the same standard.
Scientifically validated performance and longevity protocols — rooted in the same research, backed by the same experts, held to the same standard.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not approved or evaluated for safety, efficacy, or quality by the FDA.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not approved or evaluated for safety, efficacy, or quality by the FDA.
© 2026 Enhanced. All Rights Reserved. “Enhanced” and “Enhanced Games” are registered trademarks of Enhanced Group, Inc.
© 2026 Enhanced. All Rights Reserved. “Enhanced” and “Enhanced Games” are registered trademarks of Enhanced Group, Inc.